NAD+
500mg vial
A$ 249Rp 2.800.000
A coenzyme that plays a central role in cellular energy production, DNA repair, and mitochondrial function. Studied for longevity support, recovery from fatigue and burnout, and improvements in metabolic and cognitive function.
Compound overview
What it is
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every living cell, essential for over 500 enzymatic reactions. It is the central electron carrier in the mitochondrial electron transport chain (energy production), a required substrate for sirtuins (longevity-associated deacetylases), and a necessary cofactor for PARP enzymes (DNA damage repair). NAD+ levels decline with age, chronic illness, alcohol use, and metabolic stress. Restoring NAD+ levels activates cellular repair and energy pathways that slow or reverse.
Cellular energy production improves — users frequently report significant improvement in energy, mental clarity, and physical stamina within the first few IV or high-dose subcutaneous sessions. DNA repair enzyme activity increases. Mitochondrial biogenesis is supported via sirtuin activation. Cognitive function, mood, and metabolic markers improve over sustained protocols.
Studied outcomes
- Increased sirtuin activity and associated longevity pathway activation
- Improved mitochondrial function and energy production markers
- Reduction in fatigue and improvement in physical performance
- DNA repair capacity enhancement
- Improvements in metabolic markers including insulin sensitivity
Suitability
Who it's for
- Chronic fatigue, burnout, or post-viral fatigue (long COVID)
- Longevity and anti-ageing protocols
- Metabolic and cognitive optimisation
- Recovery from alcohol use, liver stress, or long-term metabolic depletion
- Pairing with mitochondrial-targeted compounds (MOTS-c, SS-31)
Who should avoid it
- Pregnancy (limited data)
- Those with active malignancy — sirtuin activation may have tumour-promoting implications in some cancer types (discuss with oncologist)
- Oral supplementation should not be assumed equivalent to injectable NAD+ — bioavailability differs significantly
Dosing guidance
Protocol guidance
Dose
250–500mg per session
Frequency
Daily for intensive cycles; 2–3× per week for maintenance
Cycle length
5–10 day intensive loading; ongoing 2–3× weekly
Route
Subcutaneous injection or slow IV infusion (IV produces faster CNS effects)
Timing
Morning preferred — energy and alertness effects are significant
Safety
Contraindications & cautions
- IV administration can cause flushing, nausea, tightness — rate control is critical for IV; subcutaneous avoids these
- Subcutaneous injection site may sting at higher concentrations — dilute adequately
- Avoid evening dosing if sleep disruption is a concern
- Stimulating effect — users with anxiety should titrate carefully
Stacking
Pairs well with
Dual mitochondrial support — MOTS-c activates AMPK, NAD+ fuels electron transport and sirtuin pathways
SS-31 protects mitochondrial membrane integrity; NAD+ fuels mitochondrial function
Combined longevity protocol — antioxidant defence + NAD+-mediated cellular repair
Not medical advice. Not a substitute for medical care. Consult your licensed practitioner before beginning any protocol. Peptides are sold for research purposes only and are suitable for adults aged 18 years and over.